Navigating the Challenges of VG Titer Assays in Gene Therapy: Accuracy, Sensitivity, & Standardisation
Time: 12:30 pm
day: Day One
Details:
Discuss the challenges of distinguishing between full and empty viral particles in VG titer assays and the impact this has on the reliability of potency assessments for gene therapies
- Explore how the sensitivity and specificity of VG titer assays can be affected by sample quality, contamination, assay method, and strategies to mitigate these issues for more accurate titer measurements
- Address the lack of universal standardisation across VG titer assay platforms and the importance of assay validation to meet regulatory requirements, ensuring reproducibility and consistency across manufacturing sites
