Michel Degueldre
Gene Therapy Biophysical Sciences Lead UCB
Seminars
Wednesday 6th May 2026
Ensuring Gene Therapy Safety by Monitoring Chemical Integrity & Degradation Pathways in Viral & Non-Viral Products
4:00 pm
- Detecting deamination, oxidation, backbone cleavage and other chemical degradations that compromise safety even when identity appears intact
- Using HPLC-UV, LC-MS and mass photometry to identify early degradation signatures before potency drops
- Correlating degradation signatures with functional potency and clinical behaviour
- Understanding how chemical instability drives immunogenicity or unexpected clinical reactions
