Jaya Kenth
Senior Associate - Research AviadoBio
Seminars
Thursday 7th May 2026
Unlocking High-Resolution Product Insight with Capillary Electrophoresis for Next-Generation Gene Therapy Characterisation
9:00 am
- Detecting subtle product heterogeneity and post-translational modifications across upstream and downstream process steps
- Leveraging CE readouts to diagnose purification bottlenecks, improve capsid quality during downstream steps, and link analytical findings to process parameters
- Using practical case studies to show when CE outperforms other methods for resolution, turnaround time, and cost, and where hybrid analytical panels are still required
Thursday 7th May 2026
Roundtable Discussion: Current Tools & Practical Considerations for Capsid Characterisation Across Development & GMP QC
9:45 am
- Discussing opportunities for in-line characterisation as a low-cost, high throughput analytical method
- Establishing a GMP QC assay of percentage empty/partial/full capsids
- Defining fit-for-purpose reporting, through understanding why percentage full readings may be sufficient for regulatory submissions
- Interpreting percentage full and partial capsid data in the absence of defined thresholds, exploring what different distributions may indicate, where uncertainty remains, and how teams are currently contextualising results without clear industry benchmarks
