Ensuring Gene Therapy Safety by Monitoring Chemical Integrity & Degradation Pathways in Viral & Non-Viral Products

• Detecting deamination, oxidation, backbone cleavage and other chemical degradations that compromise safety even when identity appears intact
• Using HPLC-UV, LC-MS and mass photometry to identify early degradation signatures before potency drops
• Correlating degradation signatures with functional potency and clinical behaviour
• Understanding how chemical instability drives immunogenicity or unexpected clinical reactions

Speakers:

Michel Degueldre

Gene Therapy Biophysical Sciences Lead

UCB