Christine LE BEC

Christine LE BEC

Company: Sensorion

Job title: Head of CMC Gene Therapy

Seminars:

Developing Functional Analytical Assays for the Characterisation of Dual AAVs 1:30 pm

The dual vector approach consists in dividing the gene of interest in two parts, one vector encoding the 5’ sequence and the other the 3’ sequence.  In vitro bioassays to demonstrate the dual otoferlin vector expresses full-length human otoferlin mRNA and protein. Determination of the optimal ratio vector for efficient reconstitution. In vivo functional assays…Read more

day: Track A Day 1 PM

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