TEM Analysis for Insights on AAV Full/Empty/Intermediate Capsid Ratios and Other Process-Critical Quality Parameters

Time: 10:15 am
day: Day One


  • Transmission electron microscopy (TEM) image analysis provides unique visual insights and capabilities to identify structural parameters related to important biological functions for quality control, efficacy, and safety
  • We present how GMP-compliant TEM analyses can be applied from preclinical stages to commercial manufacturing in gene therapy development, including specific examples of cryoTEM characterization of full/empty/intermediate capsid ratio in AAV products