Identifying mRNA production related impurities with a HPLC analytical platform

Time: 3:30 pm
day: Day One


  • Optimizing the IVT reaction for a high mRNA yield requires construct-specific considerations. While the IVT reaction might seem simple compared to cell lysates, containing mostly nucleotides and their by-products, effective IVT and subsequent purification process development needs to separate & identify these species, so they can be tracked & removed. The PATfix mRNA analytical platform is specifically designed to tackle this task.