Assessing Critical Quality Attributes of Viral Vectors for Gene Therapy
Time: 12:30 pm
day: Track B Day 2
Several quality attributes of AAV-gene therapy vectors are critical, including particle size and concentration, protein stability, monomer/dimer content, quantification of impurities (e.g., host-cell proteins) and the differentiation between empty and full capsid. In this talk, data from different analytical techniques (incl. DSF, TEM, IEX and AUC) are shown and the benefits and limitations of each technique on measuring final DP or during the manufacturing or purification steps are discussed.